RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Nanotechnology has provided great opportunities for managing neoplastic conditions at
various levels, from preventive and diagnostic to therapeutic fields. However, when it comes …

Respiratory diseases are a global burden, with millions of deaths attributed to pulmonary
illnesses and dysfunctions. Therapeutics have been developed, but they present major …

The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …

Macrophages (Mϕs) critically contribute to wound healing by coordinating inflammatory,
proliferative, and angiogenic processes. A proper switch from proinflammatory M1 to anti …

Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological
information between cells. However, Exo are limited in terms of their abilities to target …

Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …

Excessive oxidative stress and inflammation are the key early events in the development of
intervertebral disc degeneration (IVDD). The NACHT, LRR, and PYD domain-containing …

Interactions of lung macrophages and recruited neutrophils with the lung microenvironment
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …