The drug development process is a major challenge in the pharmaceutical industry since it
takes a substantial amount of time and money to move through all the phases of develo** …

While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

Drug discovery and repositioning are important processes for the pharmaceutical industry.
These processes demand a high investment in resources and are time-consuming. Several …

Abstract Mammalian cytochrome P450 1A (CYP1A) are key phase I xenobiotic‐metabolizing
enzymes that play a distinctive role in metabolic activation or metabolic clearance of a …

Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an
important role in the metabolism of endogenous as well as exogenous substances …

This work reports on a complex in silico assessment of the ADME properties of Salubrinal
(S1) and 54 of its structural analogues containing a cinnamic acid residue (S2–S40) or a …

Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with
primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes …

The inter-individual differences in cancer susceptibility are somehow correlated with the
genetic differences that are caused by the polymorphisms. These genetic variations in drug …

Oxylipins are bioactive lipid oxidation products, have vital regulatory roles in numerous
physiological processes including inflammation, and can be impacted by diet. This study …

Computer-assisted drug design (CADD) methods have greatly contributed to the
development of new drugs. Among CADD methodologies, virtual screening (VS) can enrich …