[HTML][HTML] Metabolic zonation of the liver: The oxygen gradient revisited
T Kietzmann - Redox biology, 2017 - Elsevier
The liver has a multitude of functions which are necessary to maintain whole body
homeostasis. This requires that various metabolic pathways can run in parallel in the most …
homeostasis. This requires that various metabolic pathways can run in parallel in the most …
Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics
Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …
development, including tumor invasion and metastasis, cancer stemness, and therapy …
Fate-map** post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
Hypoxia is known to be detrimental in cancer and contributes to its development. In this
work, we present an approach to fate-map hypoxic cells in vivo in order to determine their …
work, we present an approach to fate-map hypoxic cells in vivo in order to determine their …
[HTML][HTML] Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments
Inactivation of cancer stem cells (CSCs) is of utmost importance for tumor cure after
radiotherapy. An increasing body of evidence complies with a higher radioresistance of …
radiotherapy. An increasing body of evidence complies with a higher radioresistance of …
A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms
M Cojoc, K Mäbert, MH Muders, A Dubrovska - Seminars in cancer biology, 2015 - Elsevier
Similar to normal tissue, many tumors have a hierarchical organization where tumorigenic
cancer stem cells (CSCs) differentiate into non-tumorigenic progenies. A host of studies …
cancer stem cells (CSCs) differentiate into non-tumorigenic progenies. A host of studies …
Analytic models of oxygen and nutrient diffusion, metabolism dynamics, and architecture optimization in three-dimensional tissue constructs with applications and …
RJ McMurtrey - Tissue Engineering Part C: Methods, 2016 - liebertpub.com
Diffusion models are important in tissue engineering as they enable an understanding of
gas, nutrient, and signaling molecule delivery to cells in cell cultures and tissue constructs …
gas, nutrient, and signaling molecule delivery to cells in cell cultures and tissue constructs …
Hypoxia or in situ normoxia: The stem cell paradigm
Z Ivanovic - Journal of cellular physiology, 2009 - Wiley Online Library
Although O2 concentrations are considerably lowered in vivo, depending on the tissue and
cell population in question (some cells need almost anoxic environment for their …
cell population in question (some cells need almost anoxic environment for their …
Postischemic revascularization: from cellular and molecular mechanisms to clinical applications
After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …
cellular, and extracellular responses that determine the function and the remodeling of the …
Nonalcoholic fatty liver disease in children: unique considerations and challenges
D Goldner, JE Lavine - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence in concert with the
global epidemic of obesity and is being diagnosed at increasingly younger ages. The …
global epidemic of obesity and is being diagnosed at increasingly younger ages. The …
The effect of hypoxia and hypoxia-associated pathways in the regulation of antitumor response: friends or foes?
Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …