INTRODUCTION Despite their key biological roles, only a few proteins that fold into lipid
membranes have been designed de novo. A class of membrane proteins—transmembrane …

Active sites and ligand-binding cavities in native proteins are often formed by curved β
sheets, and the ability to control β-sheet curvature would allow design of binding proteins …

The PAR-1–MARK pathway controls cell polarity through the phosphorylation of microtubule-
associated proteins. Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which …

Studying the antibody response to SARS-CoV-2 informs on how the human immune system
can respond to antigenic variants as well as other SARS-related viruses. Here, we …

Abstract Knowledge of the 3D structure of proteins is a valuable asset for understanding
their precise biological mechanisms. However, the cost of production of 3D structures and …

Proteins often possess several motifs and the ones with similar motifs were found to have
similar biochemical properties and thus related biological functions. Thereby, multiple …

Arrestins halt cell signaling by binding to phosphorylated activated G protein-coupled
receptors. Arrestin-1 binds to rhodopsin, arrestin-4 binds to cone opsins, and arrestins-2, 3 …

The binding affinity of antibodies to specific antigens stems from a remarkably broad
repertoire of hypervariable loops known as complementarity-determining regions (CDRs) …

Protein structures are highly dynamic macromolecules. This dynamics is often analysed
through experimental and/or computational methods only for an isolated or a limited number …

A first step toward three-dimensional protein structure description is the characterization of
secondary structure. The most widely used program for secondary structure assignment …