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Treatment of infections caused by extended-spectrum-beta-lactamase-, AmpC-, and carbapenemase-producing Enterobacteriaceae
Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …
challenging, and some of the few active drugs are not available in many countries. For …
The “old” and the “new” antibiotics for MDR gram-negative pathogens: for whom, when, and how
The recent expansion of multidrug resistant and pan-drug-resistant pathogens poses
significant challenges in the treatment of healthcare associated infections. An important …
significant challenges in the treatment of healthcare associated infections. An important …
International consensus guidelines for the optimal use of the polymyxins: endorsed by the American college of clinical pharmacy (ACCP), European society of clinical …
The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …
1950s and thus did not undergo contemporary drug development procedures. Their clinical …
Antibiotic combination therapy against resistant bacterial infections: synergy, rejuvenation and resistance reduction
ABSTRACT Introduction: Anti-Microbial Resistance (AMR) is a pandemic which threatens
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …
[HTML][HTML] Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli
Background: The superiority of combination therapy for carbapenem-resistant Gram-
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …
Therapeutic options for metallo-β-lactamase-producing enterobacterales
The spread of metallo-β-lactamase (MBL)-producing Enterobacterales worldwide without
the simultaneous increase in active antibiotics makes these organisms an urgent public …
the simultaneous increase in active antibiotics makes these organisms an urgent public …
Emerging Gram negative resistance to last-line antimicrobial agents fosfomycin, colistin and ceftazidime-avibactam–epidemiology, laboratory detection and treatment …
ABSTRACT Introduction: Multidrug-resistant (MDR) and extensively-drug-resistant (XDR)
Gram-negative bacteria have emerged as a major threat to human health globally. This has …
Gram-negative bacteria have emerged as a major threat to human health globally. This has …
Application of the hollow fibre infection model (HFIM) in antimicrobial development: a systematic review and recommendations of reporting
Objectives This systematic review focuses on the use of the in vitro hollow fibre infection
model (HFIM) for microbial culture. We summarize the direction of the field to date and …
model (HFIM) for microbial culture. We summarize the direction of the field to date and …
[HTML][HTML] Assessment of the susceptibility of clinical Gram-negative and Gram-positive bacterial strains to fosfomycin and significance of this antibiotic in infection …
B Kowalska-Krochmal, B Mączyńska… - Pathogens, 2022 - mdpi.com
Multidrug resistance of bacteria has prompted intensive development work on new
medicines, but also the search for effective options among the oldest antibiotics. Although …
medicines, but also the search for effective options among the oldest antibiotics. Although …
New microbiological aspects of fosfomycin
The discovery of fosfomycin more than 40 years ago was an important milestone in antibiotic
therapy. The antibiotic's usefulness, alone or in combination, for treating infections caused …
therapy. The antibiotic's usefulness, alone or in combination, for treating infections caused …