Parkinson disease (PD) is characterized by loss of the A9 nigral neurons that provide
dopaminergic innervation to the striatum. This discovery led to the successful instigation of …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Generation of precisely patterned neural cells from human pluripotent stem cells (hPSCs) is
instrumental in develo** disease models and stem cell therapies. Here, we provide a …

Long non‐coding RNAs (lncRNAs) are a numerous class of newly discovered genes in the
human genome, which have been proposed to be key regulators of biological processes …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Background Neural induction of human pluripotent stem cells often yields heterogeneous
cell populations that can hamper quantitative and comparative analyses. There is a need for …

When cultured in suspension without antidifferentiation factors, embryonic stem (ES) cells
spontaneously differentiate and form three-dimensional multicellular aggregates called …

Electroactive scaffolds derived from carbohydrate hydrogels were synthesized, resulting in a
large shift in the conductivity of chitosan (CS) from 10− 6 S/cm to about 10-3 S/cm, assigned …

Human induced pluripotent stem cells (iPSCs) reprogrammed from somatic cells represent a
promising unlimited cell source for generating patient-specific cells for biomedical research …

Human embryonic stem cells (hESCs) have been proposed as a source of dopamine (DA)
neurons for transplantation in Parkinson's disease (PD). We have investigated the effect of in …