Background There is lots of evidence that maternal peri-gestational metabolic, genomic and
environmental conditions are closely linked to metabolic and cardiovascular outcomes in …

The 'Developmental Origins of Health and Diseases' hypothesis posits that prenatal
maternal diet influences offspring growth and later life health outcomes. Dietary assessment …

Objectives To evaluate the association between paternal obesity and fetal development and
pregnancy complications. Study Design This prospective cohort clinical trial analyzed data …

Obesity poses a public health threat, reaching epidemic proportions. Our hypothesis
suggests that some of this epidemic stems from its transmission across generations via …

Overweight, obesity, and their comorbidities remain global health challenges. When
established early in life, overweight is often sustained into adulthood and contributes to the …

A growing body of literature highlights the important role of paternal health and
socioemotional characteristics in child development, from preconception through …

Recent evidence in humans and animals indicates an association between maternal obesity
and offspring behavioral outcomes. In humans, increased maternal body mass index has …

STUDY QUESTION Is preconception paternal health associated with pregnancy loss?
SUMMARY ANSWER Poor preconception paternal health is associated with a higher risk of …

Paternal experiences and exposures before conception can influence fetal development
and offspring phenotype. The composition of seminal plasma contributes to paternal …

Germline de novo mutations (DNMs) refer to spontaneous mutations arising during
gametogenesis, resulting in genetic changes within germ cells that are subsequently …