Cholinesterase inhibitors as Alzheimer's therapeutics
K Sharma - Molecular medicine reports, 2019 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …
syndrome of the central nervous system that causes a decline in cognitive function and …
Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease
Abstract Chalcone [(E)-1, 3-diphenyl-2-propene-1-one], a small molecule with α, β
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …
Recent advancements in the development of bioactive pyrazoline derivatives
Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …
been proven as a ubiquitous motif which is present in a number of pharmacologically …
Unveiling a versatile heterocycle: pyrazoline–a review
The design and synthesis of novel fluorescent heterocyclic dyes is a “hotspot” research area,
due to their favourable photophysical properties and crucial role in charge transfer …
due to their favourable photophysical properties and crucial role in charge transfer …
The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurological illness that causes dementia mainly
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
Synthesis, molecular modeling, and biological evaluation of 4‐[5‐aryl‐3‐(thiophen‐2‐yl)‐4,5‐dihydro‐1H‐pyrazol‐1‐yl] benzenesulfonamides toward …
In this study, 4‐[5‐aryl‐3‐(thiophen‐2‐yl)‐4, 5‐dihydro‐1H‐pyrazol‐1‐yl]
benzenesulfonamides were synthesized, and inhibition effects on AC hE, hCA I, and hCA II …
benzenesulfonamides were synthesized, and inhibition effects on AC hE, hCA I, and hCA II …
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
Synthesis, characterization, molecular docking and biological activities of novel pyrazoline derivatives
In this study, synthesis of ethyl 2‐((4‐bromophenyl) diazenyl)‐3‐oxo‐phenylpropanoate 1
was carried out and a series of new 3H‐pyrazol‐3‐ones (P1–7) were synthesized from 1 as …
was carried out and a series of new 3H‐pyrazol‐3‐ones (P1–7) were synthesized from 1 as …
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …
progressive dementia and cognitive impairment. AD poses severe health challenge in …