The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …

The RNA exosome is a conserved degradation machinery, which obtains full activity only
when associated with cofactors. The most prominent activator of the yeast nuclear exosome …

The biological role of many nonessential tRNA modifications outside of the anticodon
remains elusive despite their evolutionary conservation. We show here that m 7 G 46 …

The exosome complex of 3′→ 5′ exonucleases is an important component of the RNA-
processing machinery in eukaryotes. This complex functions in the accurate processing of …

Nearly 20% of yeast genes are required for viability, hindering genetic analysis with
knockouts. We created promoter-shutoff strains for over two-thirds of all essential yeast …

Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the
nucleolus and mostly function as guides for nucleotide modifications. While a large pool of …

The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that
participates in the processing, quality control and degradation of virtually all classes of RNA …

The past four years have seen an explosion in the number of detected RNA transcripts with
no apparent protein-coding potential. This has led to speculation that non-protein-coding …