Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

The direct genetically encoded cell-based synthesis of non-natural peptide and
depsipeptide macrocycles is an outstanding challenge. Here we programme the encoded …

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Over the past two decades, genetic code expansion (GCE)-enabled methods for
incorporating noncanonical amino acids (ncAAs) into proteins have significantly advanced …

Virtually all natural proteins are built from only 20 amino acids, and while this makes
possible all the functions they perform, the ability to encode other amino acids selected for …

The emergence of antimicrobial resistance is a global health concern and calls for the
development of novel antibiotic agents. Antimicrobial peptides seem to be promising …

A new method for cysteine–lysine cross-linking in peptides and proteins using palladium
oxidative addition complexes is presented. First, a biarylphosphine-supported palladium …

Nisin, a typical lantibiotic, has robust antimicrobial activity combined with limited cytotoxicity,
and the development of resistance to it is slow. These properties make nisin a promising …

Lantibiotics are believed to have a conceivable potential to be used as therapeutics,
especially against clinically resistant bacterial strains. However, their low solubility and poor …