Recent advances and discoveries in the mechanisms and functions of CAR T cells
This Review discusses the major advances and changes made over the past 3 years to our
understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the …
understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the …
Improving CAR-T immunotherapy: overcoming the challenges of T cell exhaustion
D Gumber, LD Wang - EBioMedicine, 2022 - thelancet.com
Chimeric antigen receptor (CAR) T cell therapy has emerged as a cancer treatment with
enormous potential, demonstrating impressive antitumor activity in the treatment of …
enormous potential, demonstrating impressive antitumor activity in the treatment of …
[HTML][HTML] A guide to cancer immunotherapy: from T cell basic science to clinical practice
The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a
central focus for engaging the immune system in the fight against cancer. Basic science …
central focus for engaging the immune system in the fight against cancer. Basic science …
A genome-scale screen for synthetic drivers of T cell proliferation
The engineering of autologous patient T cells for adoptive cell therapies has revolutionized
the treatment of several types of cancer. However, further improvements are needed to …
the treatment of several types of cancer. However, further improvements are needed to …
[HTML][HTML] Engineering CAR-T cells for next-generation cancer therapy
T cells engineered to express chimeric antigen receptors (CARs) with tumor specificity have
shown remarkable success in treating patients with hematologic malignancies and …
shown remarkable success in treating patients with hematologic malignancies and …
Engineering strategies to overcome the current roadblocks in CAR T cell therapy
T cells genetically engineered to express chimeric antigen receptors (CARs) have proven—
and impressive—therapeutic activity in patients with certain subtypes of B cell leukaemia or …
and impressive—therapeutic activity in patients with certain subtypes of B cell leukaemia or …
Recent advances in CAR-T cell engineering
R Huang, X Li, Y He, W Zhu, L Gao, Y Liu… - Journal of hematology & …, 2020 - Springer
Chimeric antigen receptor T (CAR-T) cell therapy is regarded as an effective solution for
relapsed or refractory tumors, particularly for hematological malignancies. Although the …
relapsed or refractory tumors, particularly for hematological malignancies. Although the …
Mechanisms of resistance to CAR T cell therapy
The successes with chimeric antigen receptor (CAR) T cell therapy in early clinical trials
involving patients with pre-B cell acute lymphoblastic leukaemia (ALL) or B cell lymphomas …
involving patients with pre-B cell acute lymphoblastic leukaemia (ALL) or B cell lymphomas …
CAR T cells for solid tumors: new strategies for finding, infiltrating, and surviving in the tumor microenvironment
M Martinez, EK Moon - Frontiers in immunology, 2019 - frontiersin.org
Chimeric antigen receptor (CAR) T cells, T cells that have been genetically engineered to
express a receptor that recognizes a specific antigen, have given rise to breakthroughs in …
express a receptor that recognizes a specific antigen, have given rise to breakthroughs in …
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR) …
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR) …