The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …

Convergence is the phenomenon whereby similar phenotypes evolve independently in
different lineages. One example is resistance to toxins in animals. Toxins have evolved …

Snakebite envenoming is a serious and neglected tropical disease that kills~ 100,000
people annually. High-quality, genome-enabled comprehensive characterization of toxin …

We show that three of the eleven genes of the nematode Caenorhabditis elegans that
mediate resistance to the nematocide levamisole and to other cholinergic agonists encode …

Neuro-and myotoxicological signs and symptoms are significant clinical features of
envenoming snakebites in many parts of the world. The toxins primarily responsible for the …

The discovery, about forty years ago, of a-bungarotoxin, a three-finger a-neurotoxin from
Bungarus multicinctus venom, enabled the isolation of the nicotinic acetylcholine receptor …

Boiga dendrophila (mangrove catsnake) is a colubrid snake that lives in Southeast Asian
lowland rainforests and mangrove swamps and that preys primarily on birds. We have …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

A novel heterodimeric three‐finger neurotoxin, irditoxin, was isolated from venom of the
brown treesnake Boiga irregularis (Colubridae). Irditoxin subunit amino acid sequences …

Nicotinic acetylcholine (ACh) receptors convert the binding of ACh into the opening of a
cation-conducting channel. New information about the regions of the receptor most …