The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

Misfolded protein aggregates formed by the same (homologous) or different
(heterologous/cross) sequences are the pathological hallmarks of many protein misfolding …

Metastatic prostate cancer (mCaP) remains one of the leading causes of cancer-related
death in men worldwide. Androgen receptor (AR) drives the progression of most of the …

The p53 family of proteins is comprised of p53, p63 and p73. Because the p53 DNA binding
domain (DBD) is naturally unstable and possesses an amyloidogenic sequence, it is prone …

Backgrounds p53 is a tumor suppressor that prevents cancer onset and progression, and
mutations in the p53 gene cause loss of the tumor suppressor function of the protein. The …

Amyloid-β (Aβ) and human islet polypeptide (hIAPP) are the causative agents responsible
for Alzheimer's disease (AD) and type II diabetes (T2D), respectively. While numerous …

The p53 protein is a tumor suppressor and the most often mutated protein in human cancers.
Recent studies reported that p53 mutants, including two of the common cancer mutants …

Abnormal aggregation of the microtubule-associated protein Tau is closely associated with
tauopathies, including Alzheimer's disease and chronic traumatic encephalopathy. The …

In epithelial tumors, oncoprotein E6 binds with the ubiquitin ligase E6AP to form E6/E6AP
heterodimer; then this heterodimer recruits p53 to form E6/E6AP/p53 heterotrimer and …