Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …

In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …

Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell
resource, with potential for studying disease and use in regenerative medicine. However …

Epithelial-to-Mesenchymal Transition (EMT) and its reverse–Mesenchymal to Epithelial
Transition (MET)–are hallmarks of cellular plasticity during embryonic development and …

The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo
remains controversial. We present transcriptional and functional data to identify the …

Citrullination is the post-translational conversion of an arginine residue within a protein to
the non-coded amino acid citrulline. This modification leads to the loss of a positive charge …

A small set of core transcription factors (TFs) dominates control of the gene expression
program in embryonic stem cells and other well-studied cellular models. These core TFs …

Molecular control of the pluripotent state is thought to reside in a core circuitry of master
transcription factors including the homeodomain-containing protein NANOG,, which has an …

Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog
expression. However, the mechanisms by which Nanog functions remain unclear, and in …