The metabolic syndrome

MA Cornier, D Dabelea, TL Hernandez… - Endocrine …, 2008 - academic.oup.com
Abstract The “metabolic syndrome”(MetS) is a clustering of components that reflect
overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the …

Rodent models for human polycystic ovary syndrome

KA Walters, CM Allan, DJ Handelsman - Biology of reproduction, 2012 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most frequent female endocrine disorder, affecting
5%–10% of women, causing infertility due to dysfunctional follicular maturation and …

Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

S Klaus, S Pültz, C Thöne-Reineke… - International journal of …, 2005 - nature.com
OBJECTIVE: To examine the antiobesity effect of epigallocatechin gallate (EGCG), a green
tea bioactive polyphenol in a mouse model of diet-induced obesity. METHODS: Obesity was …

Adiponectin is a novel humoral vasodilator

G Fésüs, G Dubrovska, K Gorzelniak… - Cardiovascular …, 2007 - academic.oup.com
Objectives Perivascular adipose tissue secretes an adipocyte-derived relaxing factor
(s)(ADRF) that opens Kv channels in rat arteries. Visceral fat accumulation causes adipocyte …

Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of …

C Marchesi, T Ebrahimian, O Angulo, P Paradis… - …, 2009 - Am Heart Assoc
The metabolic syndrome represents a constellation of cardiovascular risk factors that
promote the development of cardiovascular disease. Oxidative stress is a mediator of …

The genetic landscape of type 2 diabetes in mice

SM Clee, AD Attie - Endocrine reviews, 2007 - academic.oup.com
Inbred mouse strains provide genetic diversity comparable to that of the human population.
Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse …

Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian …

G Sudhakaran, A Guru, BHD Muthu, R Murugan… - Life Sciences, 2022 - Elsevier
Polycystic ovarian syndrome (PCOS) causes swollen ovaries in women at reproductive age
due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is …

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity

A Chadt, K Leicht, A Deshmukh, LQ Jiang… - Nature …, 2008 - nature.com
We previously identified Nob1 as a quantitative trait locus for high-fat diet–induced obesity
and diabetes in genome-wide scans of outcross populations of obese and lean mouse …

Adaptative nitric oxide overproduction in perivascular adipose tissue during early diet-induced obesity

M Gil-Ortega, P Stucchi, R Guzman-Ruiz, V Cano… - …, 2010 - academic.oup.com
Perivascular adipose tissue (PVAT) plays a paracrine role in regulating vascular tone. We
hypothesize that PVAT undergoes adaptative mechanisms during initial steps of diet …

Up to date with human thyroglobulin

SA Van de Graaf, C Ris-Stalpers… - Journal of …, 2001 - joe.bioscientifica.com
The superior ovarian nerve (SON) arrives at the ovary through the suspensory ligament and
innervates mainly the ovarian stroma. Most neurones from which the SON fibres originate …