Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Action mechanisms and research methods of tRNA-derived small RNAs
Y **e, L Yao, X Yu, Y Ruan, Z Li, J Guo - Signal transduction and …, 2020 - nature.com
Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
The rise of regulatory RNA
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …
suggests that RNA is not only functional as a messenger between DNA and protein but also …
Landscape of transcription in human cells
Eukaryotic cells make many types of primary and processed RNAs that are found either in
specific subcellular compartments or throughout the cells. A complete catalogue of these …
specific subcellular compartments or throughout the cells. A complete catalogue of these …
Small nucleolar RNAs: insight into their function in cancer
J Liang, J Wen, Z Huang, X Chen, B Zhang… - Frontiers in …, 2019 - frontiersin.org
Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes:
C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA …
C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA …
LTR-retrotransposon control by tRNA-derived small RNAs
Transposon reactivation is an inherent danger in cells that lose epigenetic silencing during
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
Roles and regulation of tRNA-derived small RNAs in animals
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments
High-throughput RNA sequencing has accelerated discovery of the complex regulatory roles
of small RNAs, but RNAs containing modified nucleosides may escape detection when …
of small RNAs, but RNAs containing modified nucleosides may escape detection when …
Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases
Y Shen, X Yu, L Zhu, T Li, Z Yan, J Guo - Journal of Molecular Medicine, 2018 - Springer
The number of studies on non-coding RNAs has increased substantially in recent years
owing to their importance in gene regulation. However, the biological functions of small …
owing to their importance in gene regulation. However, the biological functions of small …
tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma
Sequencing studies from several model systems have suggested that diverse and abundant
small RNAs may be derived from tRNA, but the function of these molecules remains …
small RNAs may be derived from tRNA, but the function of these molecules remains …