The emerging role of lncRNAs in the regulation of cancer stem cells

R Castro-Oropeza, J Melendez-Zajgla, V Maldonado… - Cellular Oncology, 2018 - Springer
Background Tumors contain a functional subpopulation of cells that exhibit stem cell
properties. These cells, named cancer stem cells (CSCs), play significant roles in the …

[HTML][HTML] The dark side of SOX2: cancer-a comprehensive overview

EL Wuebben, A Rizzino - Oncotarget, 2017 - ncbi.nlm.nih.gov
The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …

Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2

Y Zhan, Z Chen, S He, Y Gong, A He, Y Li, L Zhang… - Molecular Cancer, 2020 - Springer
Background Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are
potential biomarkers and key regulators of tumour development and progression. SOX2 …

Circulating long noncoding RNA act as potential novel biomarkers for diagnosis and prognosis of non‐small cell lung cancer

Y ** transcript (Sox2ot) is a long noncoding RNA (lncRNA), localized on
human chromosome 3q26. 33, which is frequently amplified in lung squamous cell …

Emerging Role of Long Non-Coding RNA SOX2OT in SOX2 Regulation in Breast Cancer

ME Askarian-Amiri, V Seyfoddin, CE Smart, J Wang… - PloS one, 2014 - journals.plos.org
The transcription factor SOX2 is essential for maintaining pluripotency in a variety of stem
cells. It has important functions during embryonic development, is involved in cancer stem …