The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

The prognostic value of FoxP3+ regulatory T cells (Tregs) in cancer remains controversial.
We did a meta-analysis to assess the prognostic effect of FoxP3+ Treg across different types …

The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …

Background: Tumour-infiltrating lymphocytes (TILs) are often found in tumours, presumably
reflecting an immune response against the tumour. We carried out a systematic review and …

Abstract CD8+ tumor-infiltrating lymphocytes (TIL) are associated with survival in a variety of
cancers. A second subpopulation of TIL, defined by forkhead box protein P3 (FoxP3) …

Abstract Both Foxp3+ CD4+ regulatory T cells (Treg cells) and local immune responses in
nonlymphoid tissues have long been recognized as important elements of a well …

As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …