The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …

Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom …

Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or
senescence is often triggered after mitotic exit. To characterize this process, we conducted …

Background: The spindle assembly checkpoint (SAC) imparts fidelity to chromosome
segregation by delaying anaphase until all sister chromatid pairs have become bipolarly …

The signaling cascade initiated in response to DNA double-strand breaks (DSBs) has been
extensively investigated in interphase cells. Here, we show that mitotic cells treated with …

Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and
aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct …

Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell
division. Multipolar spindles are often seen in human cancers and are usually associated …

DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to
survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also …