The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

Phosphorothioates have found their usefulness in the general area of oligonucleotide
therapeutic applications. Initially this modification was introduced into the antisense …

Transcription factors (TFs) represent a major class of therapeutic targets for the treatment of
human diseases including cancer. Although the biological functions and even crystal …

In this review we address the development of oligonucleotide (ON) medicines from a
historical perspective by listing the landmark discoveries in this field. The various biological …

Aging is a complex, multifactorial process resulting in several functional and esthetic
changes in the skin. These changes result from intrinsic as well as extrinsic processes, such …

Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor that governs the expression of
genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some …

Myc expression is deregulated in a wide range of human cancers and is often associated
with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that …

OBJECTIVE: The PREVENT III study was a prospective, randomized, double-blinded,
multicenter phase III trial of a novel molecular therapy (edifoligide; E2F decoy) for the …

Antibodies have been extensively used as capture and detection reagents in diagnostic
applications of proteomics‐based technologies. Proteomic assays need high sensitivity and …

Locked nucleic acid (LNA) is a nucleic acid analogue that displays unprecedented
hybridization affinity towards complementary DNA and RNA. Structural studies have shown …