The process of cellular differentiation requires the distinct spatial organization of the
microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule …

Biological networks can be used to functionally annotate genes on the basis of interaction-
profile similarities. Metrics known as association indices can be used to quantify interaction …

Motivation: Most existing methods for predicting causal disease genes rely on specific type
of evidence, and are therefore limited in terms of applicability. More often than not, the type …

Gene activity defines cell identity, drives intercellular communication, and underlies the
functioning of multicellular organisms. We present the single-cell resolution atlas of gene …

We present a toolbox for high-throughput screening of image-based Caenorhabditis
elegans phenotypes. The image analysis algorithms measure morphological phenotypes in …

The scavenging of extracellular macromolecules by engulfment can sustain cell growth in a
nutrient-depleted environment. Engulfed macromolecules are contained within vacuoles that …

Correctly identifying associations of genes with diseases has long been a goal in biology.
With the emergence of large-scale gene-phenotype association datasets in biology, we can …

Like most organisms, the nematode Caenorhabditis elegans relies heavily on
neuropeptidergic signaling. This tiny animal represents a suitable model system to study …

Mitotic cell divisions increase cell number while faithfully distributing the replicated genome
at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell …

In metazoans, fertilization triggers the assembly of an extracellular coat that constitutes the
interface between the embryo and its environment. In nematodes, this coat is the eggshell …