Recent molecular classifications of colorectal cancer (CRC) based on global gene
expression profiles have defined subtypes displaying resistance to therapy and poor …

Simple Summary The IQ motif-containing GTPase-activating protein family is comprised of
three signal scaffolding proteins that regulate a variety of biological functions by aiding …

Abstract The calcium (Ca 2+) ion is a universal signalling messenger which plays vital
physiological roles in all eukaryotes. To decode highly regulated intracellular Ca 2+ signals …

Studies of determinants of development of inhibitory Abs to factor VIII in people with
hemophilia A indicate a complex process involving multiple factors. The Hemophilia Inhibitor …

IQ motif-containing GTPase activating protein 1 (IQGAP1) plays a central role in the physical
assembly of relevant signaling networks that are responsible for various cellular processes …

We previously found IQ motif containing GTPase activating protein (IQGAP1) to be
consistently elevated in lung fibroblasts (LF) isolated from patients with scleroderma …

Abstract The Ras GTPase-activating-like protein IQGAP1 is a multimodular scaffold that
controls signaling and cytoskeletal regulation in fibroblasts and epithelial cells. However, the …

The contractile ring, which plays critical roles in cytokinesis in fungal and animal cells, has
fascinated biologists for decades. However, the basic question of how the non-muscle …

Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-
morbidity with obesity and cardiovascular diseases. There is growing evidence supporting …

Deficiency of IQGAP2, a scaffolding protein expressed primarily in liver leads to
rearrangements of hepatic protein compartmentalization and altered regulation of enzyme …