Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

J Sharifi-Rad, C Quispe, M Imran, A Rauf… - Oxidative medicine …, 2021 - Wiley Online Library
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

Nuclear factor-kappa B and its role in inflammatory lung disease

KS Alharbi, NK Fuloria, S Fuloria, SB Rahman… - Chemico-biological …, 2021 - Elsevier
Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion,
growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric …

Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

K Banik, E Khatoon, C Harsha, V Rana… - Phytotherapy …, 2022 - Wiley Online Library
The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or
Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots …

Genistein: a potent anti-breast cancer agent

SS Bhat, SK Prasad, C Shivamallu, KS Prasad… - Current Issues in …, 2021 - mdpi.com
Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide
range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations …

Antioxidant and anti-inflammation effects of dietary phytochemicals: The Nrf2/NF-κB signalling pathway and upstream factors of Nrf2

S Wu, X Liao, Z Zhu, R Huang, M Chen, A Huang… - Phytochemistry, 2022 - Elsevier
Oxidative stress (OS) is created by an imbalance between reactive oxygen species and
antioxidant levels. OS promotes inflammation and is associated with many diseases, such …

Molecular pathways of genistein activity in breast cancer cells

EK Konstantinou, A Gioxari, M Dimitriou… - International Journal of …, 2024 - mdpi.com
The most common malignancy in women is breast cancer. During the development of
cancer, oncogenic transcription factors facilitate the overproduction of inflammatory …

COVID-19, cytokines, inflammation, and spices: How are they related?

AB Kunnumakkara, V Rana, D Parama, K Banik… - Life sciences, 2021 - Elsevier
Background Cytokine storm is the exaggerated immune response often observed in viral
infections. It is also intimately linked with the progression of COVID-19 disease as well as …

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

D Parama, M Boruah, K Yachna, V Rana, K Banik… - Life sciences, 2020 - Elsevier
Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

The role of bioactive compounds in natural products extracted from plants in cancer treatment and their mechanisms related to anticancer effects

M Yuan, G Zhang, W Bai, X Han, C Li… - Oxidative Medicine and …, 2022 - Wiley Online Library
Cancer is one of the greatest causes of death worldwide. With the development of surgery,
radiotherapy, and medical agents, the outcomes of cancer patients have greatly improved …

Blueberries and their bioactives in the modulation of oxidative stress, inflammation and cardio/vascular function markers: A systematic review of human intervention …

D Martini, M Marino, S Venturi, M Tucci… - The Journal of …, 2023 - Elsevier
Blueberries represent a rich source of (poly) phenols and other bioactive compounds.
Numerous in vitro and animal model studies documented the potential health-promoting …