The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Kinesins are a family of molecular motors that travel unidirectionally along microtubule
tracks to fulfil their many roles in intracellular transport or cell division. Over the past few …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Microtubules have long been considered an ideal target for anticancer drugs because of the
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …

Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move
along the surface of, or destabilize, microtubule filaments. Much progress has been made in …

The efficacy of current antimitotic cancer drugs is limited by toxicity in highly proliferative
healthy tissues. A cancer-specific dependency on the microtubule motor protein KIF18A …

Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

Mitotic spindle microtubules (MT s) undergo continuous poleward flux, whose driving force
and function in humans remain unclear. Here, we combined loss‐of‐function screenings …