The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to
50% of the cell mass of human tumors. TAMs are highly heterogeneous cells that originate …

RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Tumor microenvironment (TME) is composed of tumor cells and surrounding non-tumor
stromal cells, mainly including tumor associated macrophages (TAMs), endothelial cells …

The mammalian liver comprises heterogeneous cell types within its tissue microenvironment
that undergo pathophysiological reprogramming in disease states, such as non-alcoholic …

Aerobic glycolysis (the Warburg effect) has been demonstrated to facilitate tumor
progression by producing lactate, which has important roles as a proinflammatory and …

Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

Background Tumor microenvironment (TME) is a complex environment containing tumor
cells, tumor-associated macrophages (TAMs), interstitial cells, and non-cellular components …

Background Hepatocellular carcinoma (HCC) is the most common type of liver cancer.
CircFUT8 has been shown to be upregulated in cancers, but its function in HCC remains …