Metabolites are the end products of cellular regulatory processes, and their levels can be
regarded as the ultimate response of biological systems to genetic or environmental …

Metabolic flux analysis using 13C-labeled substrates has become an important tool in
metabolic engineering. It allows the detailed quantification of all intracellular fluxes in the …

13C flux analysis studies have become an essential component of metabolic engineering
research. The scope of these studies has gradually expanded to include both isotopically …

Stable isotope, and in particular 13C-based flux analysis, is the exclusive approach to
experimentally quantify the integrated responses of metabolic networks. Here we describe a …

Many properties of complex networks cannot be understood from monitoring the
components—not even when comprehensively monitoring all protein or metabolite …

Understanding in vivo regulation of photoautotrophic metabolism is important for identifying
strategies to improve photosynthetic efficiency or re-route carbon fluxes to desirable end …

Metabolic fluxes, estimated from stable isotope studies, provide a key to quantifying
physiology in fields ranging from metabolic engineering to the analysis of human metabolic …

Cell metabolism can vary considerably over the course of a typical fed‐batch antibody
production process. However, the intracellular pathway alterations associated with various …

A general methodology is presented for the modeling, simulation, design, evaluation, and
statistical analysis of 13C-labeling experiments for metabolic flux analysis. The universal …

Background The quantitative analysis of metabolic fluxes, ie, in vivo activities of intracellular
enzymes and pathways, provides key information on biological systems in systems biology …