Regulation of peptidoglycan synthesis and remodelling

AJF Egan, J Errington, W Vollmer - Nature Reviews Microbiology, 2020 - nature.com
Bacteria surround their cell membrane with a net-like peptidoglycan layer, called sacculus,
to protect the cell from bursting and maintain its cell shape. Sacculus growth during …

Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions

ME Griffin, S Klupt, J Espinosa, HC Hang - Cell chemical biology, 2023 - cell.com
The bacterial cell wall is composed of a highly crosslinked matrix of glycopeptide polymers
known as peptidoglycan that dictates bacterial cell morphology and protects against …

Mechanistic insights into the regulation of cell wall hydrolysis by FtsEX and EnvC at the bacterial division site

X Xu, J Li, WZ Chua, MA Pages, J Shi… - Proceedings of the …, 2023 - pnas.org
The peptidoglycan (PG) cell wall produced by the bacterial division machinery is initially
shared between the daughters and must be split to promote cell separation and complete …

Intrinsically disordered protein regions are required for cell wall homeostasis in Bacillus subtilis

YR Brunet, C Habib, AP Brogan, L Artzi… - Genes & …, 2022 - genesdev.cshlp.org
Intrinsically disordered protein regions (IDRs) have been implicated in diverse nuclear and
cytoplasmic functions in eukaryotes, but their roles in bacteria are less clear. Here, we report …

Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

GS Dobihal, YR Brunet, J Flores-Kim, DZ Rudner - elife, 2019 - elifesciences.org
Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from
osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge …

Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis

J Li, X Xu, J Shi, JA Hermoso, LT Sham… - Nature communications, 2023 - nature.com
The FtsEX complex regulates, directly or via a protein mediator depending on bacterial
genera, peptidoglycan degradation for cell division. In mycobacteria and Gram-positive …

Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain

J Cook, TC Baverstock, MBL McAndrew… - Proceedings of the …, 2020 - pnas.org
FtsEX is a bacterial ABC transporter that regulates the activity of periplasmic peptidoglycan
amidases via its interaction with the murein hydrolase activator, EnvC. In Escherichia coli …

The role of ATP-binding cassette transporters in bacterial phytopathogenesis

Y Zeng, AO Charkowski - Phytopathology®, 2021 - Am Phytopath Society
Bacteria use selective membrane transporting strategies to support cell survival in different
environments. Of the membrane transport systems, ATP-binding cassette (ABC) …

Not Just Transporters: Alternative Functions of ABC Transporters in Bacillus subtilis and Listeria monocytogenes

J Rismondo, LM Schulz - Microorganisms, 2021 - mdpi.com
ATP-binding cassette (ABC) transporters are usually involved in the translocation of their
cognate substrates, which is driven by ATP hydrolysis. Typically, these transporters are …

Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae

HC Lim, JW Sher, FP Rodriguez-Rivera… - PLoS …, 2019 - journals.plos.org
Several important human pathogens are represented in the Corynebacterineae suborder,
including Mycobacterium tuberculosis and Corynebacterium diphtheriae. These bacteria are …