Membrane interactions and cell selectivity of amphiphilic anticancer peptides
L Nyström, M Malmsten - Current Opinion in Colloid & Interface Science, 2018 - Elsevier
Following considerable research efforts on antimicrobial effects by cationic and amphiphilic
peptides during the last couple of decades, increasing focus has recently been placed on …
peptides during the last couple of decades, increasing focus has recently been placed on …
A pH-Dependent Coarse-Grained Model for Disordered Proteins: Histidine Interactions Modulate Conformational Ensembles
Histidine (His) presents a unique challenge for modeling disordered protein conformations,
as it is versatile and occurs in both the neutral (His0) and positively charged (His+) states …
as it is versatile and occurs in both the neutral (His0) and positively charged (His+) states …
In situ pH measurements of individual levitated microdroplets using aerosol optical tweezers
The pH of microscale reaction environments controls numerous physicochemical processes,
requiring a real-time pH microprobe. We present highly accurate real-time pH …
requiring a real-time pH microprobe. We present highly accurate real-time pH …
Computational design of pore-forming peptides with potent antimicrobial and anticancer activities
Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics
for bacterial infections and cancer. However, their optimization for clinical translation is …
for bacterial infections and cancer. However, their optimization for clinical translation is …
The physical basis for pH sensitivity in biomolecular structure and function, with application to the spike protein of SARS-CoV-2
J Warwicker - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Since pH sensitivity has a fundamental role in biology, much effort has been committed to
establishing physical models to rationalize and predict pH dependence from molecular …
establishing physical models to rationalize and predict pH dependence from molecular …
A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques
K Yamaguchi, YO Kamatari, F Ono, H Shibata… - Nature Biomedical …, 2019 - nature.com
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases
that lack therapeutic solutions. Here, we show that the molecular chaperone (N, N …
that lack therapeutic solutions. Here, we show that the molecular chaperone (N, N …
Histidine network regulates the structure-stability features of T7 endolysin native and partially folded conformations
Conformational transitions displayed by proteins are a classical phenomenon associated
with the structural intricacies that directly influence concomitant functionality. pH-dependent …
with the structural intricacies that directly influence concomitant functionality. pH-dependent …
Met/Val129 polymorphism of the full-length human prion protein dictates distinct pathways of amyloid formation
T Pauly, N Bolakhrif, J Kaiser, L Nagel-Steger… - Journal of Biological …, 2022 - ASBMB
Methionine/valine polymorphism at position 129 of the human prion protein, huPrP, is tightly
associated with the pathogenic phenotype, disease progress, and age of onset of …
associated with the pathogenic phenotype, disease progress, and age of onset of …
In Vitro Approach To Identify Key Amino Acids in Low Susceptibility of Rabbit Prion Protein to Misfolding
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of rare
progressive neurodegenerative disorders caused by an abnormally folded prion protein …
progressive neurodegenerative disorders caused by an abnormally folded prion protein …
Structural insight into conformational change in prion protein by breakage of electrostatic network around H187 due to its protonation
J Lee, I Chang - Scientific reports, 2019 - nature.com
A conformational change from normal prion protein (PrPC) to abnormal prion protein
(PrPSC) induces fatal neurodegenerative diseases. Acidic pH is well-known factors involved …
(PrPSC) induces fatal neurodegenerative diseases. Acidic pH is well-known factors involved …