A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …

The development of a fatal, clonal, autonomously proliferating CD4− CD8− chimeric antigen
receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient …

Cancer is a complex disease in which several molecular and cellular pathways converge to
foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks,“ …

Somatic mutations accumulate in all cells with age and can confer a selective advantage,
leading to clonal expansion over time. In hematopoietic cells, mutations in a subset of genes …

Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of a
cancer-associated somatic mutation in white blood cells in the absence of overt …

DNA methylation is critical for regulating gene expression, necessitating its accurate
placement by enzymes such as the DNA methyltransferase DNMT3A. Dysregulation of this …

Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …

Abstract DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and
maintaining DNA methylation patterns in vertebrates. Here we structurally and biochemically …