▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Deep generative neural networks have been used increasingly in computational chemistry
for de novo design of molecules with desired properties. Many deep learning approaches …

Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an
efficient way to determine kinase inhibitor specificity by measuring binding of small …

The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have
been invaluable tools for elucidating the roles of these enzymes in signal transduction …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Abbreviations: AMP-K, AMP-activated protein kinase;/3ARK,/3 adrenergic receptor kinase;
BCKDHK, branched chain ketoglutaric acid dehydrogenase; CaM-kinases, calmodulin …

Although glycogen synthase kinase‐3 beta (GSK‐3β) was originally named for its ability to
phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional …

Shutoff of global protein synthesis is a conserved response to cellular stresses. This general
phenomenon is accompanied by the induction of distinct gene programs tailored to each …

ADP-Glo™ is a novel bioluminescent, homogeneous assay for monitoring ADP producing
biochemical reactions and thus it is an ideal assay for detecting enzyme activity using a wide …