Across all branches of the immune system, the process of autophagy is fundamentally
important in cellular development, function and homeostasis. Strikingly, this evolutionarily …

Autophagy, a cellular waste disposal process, has well-established tumor-suppressive
properties. New studies indicate that, in addition to its cell-autonomous anti-tumorigenic …

The production of pore-forming toxins that disrupt the plasma membrane of host cells is a
common virulence strategy for bacterial pathogens such as methicillin-resistant …

Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and
dysbiosis of the gut microbiome, though unifying principles for these findings remain largely …

Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …

A variant of the autophagy gene ATG16L1 is associated with Crohn's disease, an
inflammatory bowel disease (IBD), and poor survival in allogeneic hematopoietic stem cell …

Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is
critical to mount a host defense or repair tissue. The exact molecular mechanisms controlling …

Autophagy and immunity share the property of being auto-protective for the organism.
Autophagy is an important degradation pathway that buffers nutrient deprivation by recycling …

The macroautophagy machinery has been implicated in MHC class II restricted antigen
presentation. Here, we report that this machinery assists in the internalization of MHC class I …