Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9
(Cas9) is a precise genome manipulating technology that can be programmed to induce …

INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …

The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …

Abstract 53BP1 is an enigmatic DNA damage response factor that gained prominence
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …

Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly
completion of genome duplication, and its malfunction may lead to catastrophic genome …

Mutations in the BRCA1 and BRCA2 genes predispose afflicted individuals to breast,
ovarian, and other cancers. The BRCA-encoded products form complexes with other tumor …

Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …

Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are
considered to form through homologous recombination (HR). Indeed, SCE induction upon …

Cancer cells rely on the activation of telomerase or the alternative lengthening of telomeres
(ALT) pathways for telomere maintenance and survival. ALT involves homologous …