The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Autophagy refers to the formation of autophagosomes by membrane wrap** part of the
cytoplasm and the organelles and proteins that need to be degraded in the cells …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting
(IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …

Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …