The mechanics of traumatic brain injury: a review of what we know and what we need to know for reducing its societal burden
Traumatic brain injury (TBI) is a significant public health problem, on pace to become the
third leading cause of death worldwide by 2020. Moreover, emerging evidence linking …
third leading cause of death worldwide by 2020. Moreover, emerging evidence linking …
Use of brain biomechanical models for monitoring impact exposure in contact sports
Head acceleration measurement sensors are now widely deployed in the field to monitor
head kinematic exposure in contact sports. The wealth of impact kinematics data provides …
head kinematic exposure in contact sports. The wealth of impact kinematics data provides …
Traumatic brain injury and the neuronal microenvironment: a potential role for neuropathological mechanotransduction
Traumatic brain injury (TBI) is linked to several pathologies for which there is a lack of
understanding of disease mechanisms and therapeutic strategies. To elucidate injury …
understanding of disease mechanisms and therapeutic strategies. To elucidate injury …
Neuroimaging biomarkers in mild traumatic brain injury (mTBI)
ED Bigler - Neuropsychology review, 2013 - Springer
Reviewed herein are contemporary neuroimaging methods that detect abnormalities
associated with mild traumatic brain injury (mTBI). Despite advances in demonstrating …
associated with mild traumatic brain injury (mTBI). Despite advances in demonstrating …
Brain injury tolerance limit based on computation of axonal strain
D Sahoo, C Deck, R Willinger - Accident Analysis & Prevention, 2016 - Elsevier
Traumatic brain injury (TBI) is the leading cause of death and permanent impairment over
the last decades. In both the severe and mild TBIs, diffuse axonal injury (DAI) is the most …
the last decades. In both the severe and mild TBIs, diffuse axonal injury (DAI) is the most …
Group-wise evaluation and comparison of white matter fiber strain and maximum principal strain in sports-related concussion
Sports-related concussion is a major public health problem in the United States and yet its
biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation …
biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation …
An analytical review of the numerical methods used for finite element modeling of traumatic brain injury
Dozens of finite element models of the human brain have been developed for providing
insight into the mechanical response of the brain during impact. Many models used in …
insight into the mechanical response of the brain during impact. Many models used in …
Finite element methods in human head impact simulations: a review
Head impacts leading to traumatic brain injury (TBI) present a major health risk today,
projected to become the third leading cause of death by 2020. While finite element (FE) …
projected to become the third leading cause of death by 2020. While finite element (FE) …
Embedded axonal fiber tracts improve finite element model predictions of traumatic brain injury
With the growing rate of traumatic brain injury (TBI), there is an increasing interest in
validated tools to predict and prevent brain injuries. Finite element models (FEM) are …
validated tools to predict and prevent brain injuries. Finite element models (FEM) are …
Development and validation of an advanced anisotropic visco-hyperelastic human brain FE model
D Sahoo, C Deck, R Willinger - Journal of the mechanical behavior of …, 2014 - Elsevier
This paper proposes the implementation of fractional anisotropy and axonal fiber orientation
from diffusion tensor imaging (DTI) of 12 healthy patients into an existing human FE head …
from diffusion tensor imaging (DTI) of 12 healthy patients into an existing human FE head …