Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark
heavy‐chain antibodies, have many desirable properties as components of biologic drugs …

The B cell receptor and secreted antibody are at the nexus of humoral adaptive immunity. In
this review, we summarize what is known of the immunoglobulin genes of jawed …

Peptides and small protein scaffolds are gaining increasing interest as therapeutics.
Similarly to full-length antibodies, they can bind a target with a high binding affinity and …

Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of
small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it …

Highlights•A variety of albumin-binding moieties (ABMs) have been developed for half-life
extension of short-lived drugs.•Various drugs can incorporate a selected ABM for in situ HSA …

Highlights•Camelids and sharks comprise heavy chain-only antibodies devoid of light
chains.•Their variable domains are able to address cryptic and recessed epitopes.•These …

Bispecific antibodies have moved from being an academic curiosity with therapeutic promise
to reality, with two molecules being currently commercialized (Hemlibra® and Blincyto®) …

In addition to antibodies with the classical composition of heavy and light chains, the
adaptive immune repertoire of sharks also includes a heavy-chain only isotype, where …

Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements
as they combine the advantages of the specificity and affinity found in conventional …

Sensitive detection of cancer biomarkers can contribute to the timely diagnosis and
treatment of diseases. In this study, the whitespotted bamboo sharks were immunized with …