Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Abstract Purpose of Review To present a comprehensive overview regarding criteria,
epidemiology, and controversies that have arisen in the literature about the existence and …

Accumulating evidence indicates that obesity is closely associated with an increased risk of
metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and …

Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver
diseases in the Western society and its prevalence is likely to rise even further. An …

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to
the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin …

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.
Treatment of type 2 diabetes has been limited by little translational knowledge of insulin …

Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex,
genetic background, disease state, certain drugs and hormones, development, and aging …

Background—Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) vary in
volume and quality. We evaluated whether fat volume or attenuation (indirect measure of …

Genetics, epigenetics, and environment may together affect the susceptibility for type 2
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …