Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

RJ Obaid, N Naeem, EU Mughal, MM Al-Rooqi… - RSC …, 2022 - pubs.rsc.org
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …

Pharmacological significance of nitrogen-containing five and six-membered heterocyclic scaffolds as potent cholinesterase inhibitors for drug discovery

RJ Obaid, EU Mughal, N Naeem, MM Al-Rooqi… - Process …, 2022 - Elsevier
N-heterocycles are crucial due to their biological, chemical, and practical significance. They
are heavily investigated in biological processes involving anticancer, anti-inflammatory …

[HTML][HTML] Advancement of chitin and chitosan as promising biomaterials

MM Al-Rooqi, MM Hassan, Z Moussa, RJ Obaid… - Journal of Saudi …, 2022 - Elsevier
Biopolymers like cellulose, polysaccharides, chitosan, starch, chitin, and alginates have
sparked an increasing curiosity in creating natural replacements for synthetic polymers …

Active pharmaceutical ingredients (APIs) in ionic liquids: An effective approach for API physiochemical parameter optimization

M Handa, WH Almalki, R Shukla, O Afzal… - Drug Discovery …, 2022 - Elsevier
Highlights•Ionic liquids (ILs) are ions-based substances with melting points below 100
C.•Versatile nature and properties of ILs made it as solvent and designer …

New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights

MS Malik, RI Alsantali, QMS Jamal, ZS Seddigi… - Frontiers in …, 2022 - frontiersin.org
An efficient atom-economical synthetic protocol to access new imidazole-based N-
phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized …

Recent advancements on the synthesis and biological significance of pipecolic acid and its derivatives

MM Al-Rooqi, EU Mughal, QA Raja, RJ Obaid… - Journal of Molecular …, 2022 - Elsevier
Pipecolic acids are cyclic non-protein amino acids serving as precursors for the biosynthesis
of biological metabolites. Structurally, the six-membered cyclic motif consists of five-carbons …

Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights

MS Malik, H Ather, SM Asif Ansari, A Siddiqua… - Pharmaceuticals, 2023 - mdpi.com
Indole-tethered chromene derivatives were synthesised in a one-pot multicomponent
reaction using N-alkyl-1 H-indole-3-carbaldehydes, 5, 5-dimethylcyclohexane-1, 3-dione …

[HTML][HTML] Multicomponent synthesis, cytotoxicity, and computational studies of novel imidazopyridazine-based N-phenylbenzamides

MS Malik, RA Alsantali, AYA Alzahrani… - Journal of Saudi …, 2022 - Elsevier
A one-pot multicomponent synthesis and application of new imidazopyridazine based N-
phenylbenzamides is described. An atom-economical method involving dimethyl phthalate …

PVPP-p-TSA catalyzed one-step synthesis of novel aryldiazenyl-2-hydroxybenzylidene-cyanoarylhydrazide analogs

A Mosaffaeirad, M Mokhtary, M Nikpassand - Journal of Molecular Structure, 2023 - Elsevier
In this research, an efficient process for the preparation of new aryldiazenyl-2-
hydroxybenzylidene-cyanoarylhydrazide analogs was developed through the reaction of 2 …

Radical dendrimer: bis-indolyl polyurethane dendrimers containing TEMPO radicals for inhibition of cancer cell growth

I Bargathulla, B Mohamad Ali, WA Skadon… - … Science, Part A, 2024 - Taylor & Francis
Blocked isocyanate-terminated polyurethane dendrimers of first-generation (G1) to third-
generation (G3) build-up with bis-indolyl units were subjected to urethane interchange …