The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of
advantages over previous cardiac models, however, questions of their immaturity complicate …

NKX2-5 is expressed in the heart throughout life. We targeted eGFP sequences to the NKX2-
5 locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …

Cardiac hypertrophy is a major risk factor for heart failure and associated patient morbidity
and mortality. Research investigating the aberrant molecular processes that occur during …

Induced pluripotent stem cells (iPSCs) hold great hopes for therapeutic application in
various diseases. Although ongoing research is dedicated to achieving clinical translation of …

Cardiac arrhythmias are a major cause of morbidity and mortality. In younger patients, the
majority of sudden cardiac deaths have an underlying Mendelian genetic cause. Over the …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) have been
recently derived and are used for basic research, cardiotoxicity assessment, and phenotypic …

Among the disciplines of medicine, the study of neurological disorders is particularly
challenging. The fundamental inaccessibility of the human neural types affected by disease …

Drug attrition rates have increased in past years, resulting in growing costs for the
pharmaceutical industry and consumers. The reasons for this include the lack of in vitro …

During the last two decades, significant progress has been made in the identification of
genetic defects underlying inherited arrhythmia syndromes, which has provided some …