Randomized clinical trials initially used heart failure (HF) patients with low left ventricular
ejection fraction (LVEF) to select study populations with high risk to enhance statistical …

Background: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in
patients with advanced symptoms of heart failure. Purpose: To assess the benefits and …

The recommendations listed in this guideline are, whenever possible, evidence based. An
initial extensive evidence review, which included literature derived from research involving …

Aims Recent guidelines recommend that patients with heart failure and left ventricular
ejection fraction (LVEF) 40–49% should be managed similar to LVEF≥ 50%. We …

The recommendations listed in this guideline are, whenever possible, evidence based. An
initial extensive evidence review, which included literature derived from research involving …

Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT)
and conduction system pacing (CSP), has emerged as a pacing therapy strategy that may …

Background—Appropriate guideline criteria for use of implantable cardioverter-defibrillators
(ICDs) do not take into account potential recovery of left ventricular ejection fraction (LVEF) …

Aims The independent clinical correlates and prognostic impact of QRS prolongation in
heart failure (HF) with reduced and preserved ejection fraction (EF) are poorly understood …

Abstract Aims The Pacing to Avoid Cardiac Enlargement (PACE) trial is a prospective,
double-blinded, randomized, multicentre study that reported the superiority of biventricular …

Characterized by a rapidly increasing prevalence, elevated mortality and rehospitalization
rates, and inadequacy of pharmaceutical therapies, heart failure with preserved ejection …