[HTML][HTML] Nanopore sequencing technology, bioinformatics and applications

Y Wang, Y Zhao, A Bollas, Y Wang, KF Au - Nature biotechnology, 2021 - nature.com
Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …

Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Accurate detection of m6A RNA modifications in native RNA sequences

H Liu, O Begik, MC Lucas, JM Ramirez… - Nature …, 2019 - nature.com
The epitranscriptomics field has undergone an enormous expansion in the last few years;
however, a major limitation is the lack of generic methods to map RNA modifications …

Towards a genomics-informed, real-time, global pathogen surveillance system

JL Gardy, NJ Loman - Nature Reviews Genetics, 2018 - nature.com
Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

Nanopore DNA sequencing and genome assembly on the International Space Station

SL Castro-Wallace, CY Chiu, KK John, SE Stahl… - Scientific reports, 2017 - nature.com
We evaluated the performance of the MinION DNA sequencer in-flight on the International
Space Station (ISS), and benchmarked its performance off-Earth against the MinION …

Characterization of the total and viable bacterial and fungal communities associated with the International Space Station surfaces

A Checinska Sielaff, C Urbaniak, GBM Mohan… - Microbiome, 2019 - Springer
Abstract Background The International Space Station (ISS) is a closed system inhabited by
microorganisms originating from life support systems, cargo, and crew that are exposed to …

Chiron: translating nanopore raw signal directly into nucleotide sequence using deep learning

H Teng, MD Cao, MB Hall, T Duarte, S Wang… - …, 2018 - academic.oup.com
Sequencing by translocating DNA fragments through an array of nanopores is a rapidly
maturing technology that offers faster and cheaper sequencing than other approaches …

Biological research and self-driving labs in deep space supported by artificial intelligence

LM Sanders, RT Scott, JH Yang, AA Qutub… - Nature Machine …, 2023 - nature.com
Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

Portable nanopore-sequencing technology: Trends in development and applications

P Chen, Z Sun, J Wang, X Liu, Y Bai, J Chen… - Frontiers in …, 2023 - frontiersin.org
Sequencing technology is the most commonly used technology in molecular biology
research and an essential pillar for the development and applications of molecular biology …

The impact of heterogeneity on single-cell sequencing

SL Goldman, M MacKay, E Afshinnekoo… - Frontiers in …, 2019 - frontiersin.org
The importance of diversity and cellular specialization is clear for many reasons, from
population-level diversification, to improved resiliency to unforeseen stresses, to unique …