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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan
Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very
common, affecting up to one in five women of reproductive age. It has significant and diverse …
common, affecting up to one in five women of reproductive age. It has significant and diverse …
Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline
Objective: The aim was to formulate practice guidelines for the diagnosis and treatment of
polycystic ovary syndrome (PCOS). Participants: An Endocrine Society-appointed Task …
polycystic ovary syndrome (PCOS). Participants: An Endocrine Society-appointed Task …
Cardiometabolic aspects of the polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women
of reproductive age and is associated with various metabolic perturbations, in addition to …
of reproductive age and is associated with various metabolic perturbations, in addition to …
Cardiovascular actions of insulin
Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review
Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2
diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin …
diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin …
The role of low-grade inflammation in the polycystic ovary syndrome
A Repaci, A Gambineri, R Pasquali - Molecular and cellular endocrinology, 2011 - Elsevier
PCOS is not only the most frequent cause of oligomenorrhea in young women, but also a
metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia …
metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia …
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …
glucose levels and positively affects cardiovascular function in patients with diabetes and …
Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is now recognized to be the most common
endocrinopathy in women of reproductive age with a prevalence of 6.6–6.8%. PCOS, a …
endocrinopathy in women of reproductive age with a prevalence of 6.6–6.8%. PCOS, a …
Metformin restores endothelial function in aorta of diabetic rats
BACKGROUND AND PURPOSE The effects of metformin, an antidiabetic agent that
improves insulin sensitivity, on endothelial function have not been fully elucidated. This …
improves insulin sensitivity, on endothelial function have not been fully elucidated. This …