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NADPH oxidases: from molecular mechanisms to current inhibitors
A Cipriano, M Viviano, A Feoli, C Milite… - Journal of medicinal …, 2023 - ACS Publications
NADPH oxidases (NOXs) form a family of electron-transporting membrane enzymes whose
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …
PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target
F Lind-Holm Mogensen, A Scafidi, A Poli… - Journal of …, 2023 - Springer
Microglia are the immune effector cells of the brain playing critical roles in immune
surveillance and neuroprotection in healthy conditions, while they can sustain …
surveillance and neuroprotection in healthy conditions, while they can sustain …
LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease
Oxidative stress has long been implicated in Parkinson's disease (PD) pathogenesis,
although the sources and regulation of reactive oxygen species (ROS) production are poorly …
although the sources and regulation of reactive oxygen species (ROS) production are poorly …
Structure, activation, and regulation of NOX2: At the crossroad between the innate immunity and oxidative stress-mediated pathologies
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) is a multisubunit
enzyme complex that participates in the generation of superoxide or hydrogen peroxide …
enzyme complex that participates in the generation of superoxide or hydrogen peroxide …
[HTML][HTML] Rebalancing NOX2/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine
A Ardizzone, AP Capra, A Repici, M Lanza… - Free Radical Biology …, 2024 - Elsevier
Migraine is one of the most common neurological illnesses, and it is characterized by
complicated neurobiology. It was confirmed the influence of inflammation and oxidative …
complicated neurobiology. It was confirmed the influence of inflammation and oxidative …
Endothelial and vascular smooth muscle dysfunction in hypertension
The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …
NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders
Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …
Microalgae as a potential therapeutic drug candidate for neurodegenerative diseases
Microalgae are highly photosynthetic unicellular organism that have increased demand in
the recent days owing to the presence of valuable cellular metabolites. They are ubiquitous …
the recent days owing to the presence of valuable cellular metabolites. They are ubiquitous …
Neuronal oxidative stress promotes α-synuclein aggregation in vivo
SJ Won, R Fong, N Butler, J Sanchez, Y Zhang… - Antioxidants, 2022 - mdpi.com
Both genetic and environmental factors increase risk for Parkinson's disease. Many of the
known genetic factors influence α-synuclein aggregation or degradation, whereas most of …
known genetic factors influence α-synuclein aggregation or degradation, whereas most of …
[HTML][HTML] The molecular mechanism of ferroptosis and its relationship with Parkinson's disease
Y Su, Y Jiao, Q Wang, X Chen - Brain Research Bulletin, 2024 - Elsevier
Neurodegenerative diseases such as Parkinson's disease (PD) have complex pathogenetic
mechanisms. Genetic, age, and environmental factors are all related to PD. Due to the …
mechanisms. Genetic, age, and environmental factors are all related to PD. Due to the …