The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

The prevalence of obesity has increased worldwide in the past~ 50 years, reaching
pandemic levels. Obesity represents a major health challenge because it substantially …

In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

New information regarding neuronal circuits that control food intake and their hormonal
regulation has extended our understanding of energy homeostasis, the process whereby …

The assimilation, storage and use of energy from nutrients constitute a homeostatic system
that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense …

INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …

The association of obesity with type 2 diabetes has been recognized for decades, and the
major basis for this link is the ability of obesity to engender insulin resistance. Insulin …

During the past two decades, the prevalence of obesity in children has risen greatly
worldwide. Obesity in childhood causes a wide range of serious complications, and …