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Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …
Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
Idiopathic pulmonary fibrosis: state of the art for 2023
AJ Podolanczuk, CC Thomson… - European …, 2023 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease characterised by
worsening respiratory symptoms and physiological impairment. Increasing awareness of the …
worsening respiratory symptoms and physiological impairment. Increasing awareness of the …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
Idiopathic pulmonary fibrosis
L Richeldi, HR Collard, MG Jones - The Lancet, 2017 - thelancet.com
Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …
TGF-β1 signaling and tissue fibrosis
KK Kim, D Sheppard… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …
wound repair in many organs. However, the outcome of temporary extracellular matrix …
Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells
Fibrosis can develop in most organs and causes organ failure. The most common type of
lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung …
lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung …
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
L Zhang, Y Wang, G Wu, W **ong, W Gu, CY Wang - Respiratory research, 2018 - Springer
Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial
lung disease of unknown etiology. Over the past decade, macrophage has been recognized …
lung disease of unknown etiology. Over the past decade, macrophage has been recognized …
[HTML][HTML] Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …