Revisiting host-pathogen interactions in cystic fibrosis lungs in the era of CFTR modulators

CMP Ribeiro, MG Higgs, MS Muhlebach… - International Journal of …, 2023 - mdpi.com
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators, a new series of
therapeutics that correct and potentiate some classes of mutations of the CFTR, have …

Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug‐resistant …

M Escobar‐Salom, G Torrens… - Biological …, 2022 - Wiley Online Library
Mammalian innate immunity employs several humoral 'weapons' that target the bacterial
envelope. The threats posed by the multidrug‐resistant 'ESKAPE'Gram‐negative pathogens …

Защитные стратегии нейтрофильных гранулоцитов от патогенных бактерий

БГ Андрюков, ЛМ Сомова, ЕИ Дробот… - Здоровье …, 2017 - cyberleninka.ru
Организм человека постоянно сталкивается с проблемой защиты от патогенных
бактерий, используя различные стратегии программируемой клеточной гибели (ПКГ) …

Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis

JM Holzinger, M Toelge, M Werner, KU Ederer… - Elife, 2023 - elifesciences.org
Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous
antibiotic treatment. In this context, Pseudomonas aeruginosa (Pa) is of special concern …

Bactericidal permeability increasing protein deficiency aggravates acute colitis in mice by increasing the serum levels of lipopolysaccharide

Q Kong, Z Lv, Y Kang, Y An, Z Liu, J Zhang - Frontiers in Immunology, 2021 - frontiersin.org
Objective The objective of this study was to understand the role of bactericidal permeability
increasing protein (BPI) in the pathogenesis of experimental murine colitis. Methods We …

Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from cystic fibrosis patients

JM Holzinger, M Toelge, M Werner, KU Ederer… - bioRxiv, 2023 - biorxiv.org
Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous
antibiotic treatment. In this context, Pseudomonas aeruginosa (Pa) is of special concern …

Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation

E Guinan, DE Avigan, RJ Soiffer, NJ Bunin… - …, 2015 - pmc.ncbi.nlm.nih.gov
Bacterial infection and inflammation contribute significantly to the morbidity and mortality of
myeloablative allogeneic hematopoietic cell transplantation (HCT). Endotoxin, a component …

rBPI21 (opebacan) promotes rapid trilineage hematopoietic recovery in a murine model of high‐dose total body irradiation

KJ Janec, H Yuan, JE Norton Jr… - American journal of …, 2018 - Wiley Online Library
The complexity of providing adequate care after radiation exposure has drawn increasing
attention. While most therapeutic development has focused on improving survival at lethal …

Antibakterielle und antivirale Wirkung des human bactericidal permeability increasing protein und hieraus abgeleiteter Peptide

M Rosenthal - 2023 - archiv.ub.uni-marburg.de
Die bakterielle Resistenz gegenüber antibiotischer Therapiekonzepte spielt eine wichtige
Rolle in der Medizin. Dabei können die Resistenzfaktoren der Bakterien gegenüber …

[PDF][PDF] Antibakterielle und antivirale Wirkung des human bactericidal permeability increasing protein und hieraus abgeleiteter Peptide

DS Bauer - scholar.archive.org
Bakterien lassen sich auf verschiedene Arten unterscheiden, durch die Form, das Verhalten
(Sporenbildung, anaerob/aerob) oder, für diese Arbeit am relevantesten, die histologische …