Mass cytometry has revolutionized immunophenoty**, particularly in exploratory settings
where simultaneous breadth and depth of characterization of immune populations is needed …

Tumor-associated macrophages (TAMs) play an important role in the immune response to
cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell …

Chronic inflammation can drive tumor development. Here, we have identified microRNA-
146a (miR-146a) as a major negative regulator of colonic inflammation and associated …

The PD-1 receptor triggers a negative immunoregulatory mechanism that prevents
overactivation of immune cells and subsequent inflammatory diseases. Because of its …

Eradication of pathogens from the bloodstream is critical to prevent disseminated infections
and sepsis. Kupffer cells in the liver form an intravascular firewall that captures and clears …

Previous studies have reported that microglia depletion leads to impairment of synapse
formation and these cells rapidly repopulate from CNS progenitors. However, the impact of …

The intestinal mucosa constitutes an environment of closely regulated immune cells.
Dendritic cells (DC) interact with the gut microbiome and antigens and are important in …

Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis
and treatment of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and …

Conjugated linoleic acid (CLA) has been shown to activate the nuclear receptor PPAR-γ and
modulate metabolic and immune functions. Despite the worldwide use of CLA dietary …

Kupffer cells are the primary liver resident immune cell responsible for the liver firewall
function, including clearance of bacterial infection from the circulation, as they are …