Concomitant administration of multiple drugs frequently causes severe pharmacokinetic or
pharmacodynamic drug–drug interactions (DDIs) resulting in the possibility of enhanced …

Tivozanib is a recently approved tyrosine kinase inhibitor for the treatment of renal cell
carcinoma. In this work, two new HPLC methods coupled with fluorescence (FLD), or …

Loxoprofen sodium (LOX) is a propionic acid derivative non-steroidal anti-inflammatory drug
(NSAID), existing in the form of four stereoisomers. The main metabolites of LOX in vivo …

Osthole (OST), a coumarin derivative, is one of the major components of Cnidium monnieri
(L.) Cussion. OST was reported to induce apoptosis in hepatocytes. Elevated serum ALT …

Although topical preparations like creams, ointments, and gels were used for many years to
achieve local or sometimes systemic effects, they have many limitations, mostly the inability …

Background: As an anti-inflammatory prodrug, loxoprofen is metabolized into transloprofenol
to treat diseases related to pain and inflammation. Although loxoprofen has fewer adverse …