Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …

Abstract Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in
young adults and children in the developed world, occurring in over 1.7 million persons and …

Cancer cell genetic variability and similarity to host cells have stymied development of broad
anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse …

Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of
pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of …

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in
macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD …

An abnormal neutrophil subset has been identified in the PBMC fractions from lupus
patients. We have proposed that these low-density granulocytes (LDGs) play an important …

In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation
remain poorly understood. Damage-associated molecular patterns (DAMPs) are considered …

Neutrophil granule serine proteases contribute to immune responses through cleavage of
microbial toxins and structural proteins. They induce tissue damage and modulate …

The growth factor progranulin (PGRN) has been implicated in embryonic development,
tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We …

The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …