Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

After their synthesis from cholesterol in hepatic tissues, bile acids (BAs) are secreted into the
intestinal lumen. Most BAs are subsequently re-absorbed in the terminal ileum and are …

The perturbations of the gut microbiota and metabolites are closely associated with the
progression of inflammatory bowel disease (IBD). However, inconsistent findings across …

Background Well-balanced interactions between gut microbiota and the immune system are
essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel …

The relationship among the gut microbiome, global fecal metabolites and rheumatoid
arthritis (RA) has not been systematically evaluated. In this study, we performed 16S rDNA …

ABSTRACT L-arginine (L-arg) is a versatile amino acid and a central intestinal metabolite in
mammalian and microbial organisms. Thus, L-arg participates as precursor of multiple …

Urea cycle impairment and its relationship to obesity and inflammation remained elusive,
partly due to the dramatic clinical presentation of classical urea cycle defects. We generated …

DNA damage occurs throughout tumorigenesis and development. The immunogenicity of
DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses …

Abstract Background and Aims Group 3 innate lymphoid cells [ILC3s] sense environmental
signals and are critical in gut homeostasis and immune defence. G-protein-coupled …

Altered composition of gut bacteria and changes to the production of their bioactive
metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of …