The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …

Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Abstract R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …

Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …

Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …

Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

Summary The cGAS-STING intracellular DNA-sensing pathway has emerged as a key
element of innate antiviral immunity and a promising therapeutic target. The existence of an …

Metastasis frequently develops from disseminated cancer cells that remain dormant after the
apparently successful treatment of a primary tumour. These cells fluctuate between an …